SYNERGISTIC DNA-DAMAGING EFFECT IN MULTIPLE MYELOMA WITH THE COMBINATION OF ZALYPSIS, BORTEZOMIB AND DEXAMETHASONE

Synergistic DNA-damaging effect in multiple myeloma with the combination of zalypsis, bortezomib and dexamethasone

Despite new advances in multiple myeloma treatment and the consequent improvement in overall survival, most patients relapse or become refractory to treatment.This suggests that new molecules and combinations that may further inhibit important survival pathways for these tumor cells are needed.In this context, zalypsis is a novel compound, derived

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In vitro evaluation of the herbal cream formulation from methanolic leaf extracts of Tephrosia vogelii Hook.f for topical application

Abstract Background Topical infectious are among of global challenges which propelled up with antimicrobial resistances.This scenario compels for drug discovery and development.Herbal formulation is Accessories one of important struggle in the drug development with the purpose of overcoming various diseases distressing health care settings.Thus, th

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